Ozone Therapy
Treatment

Low-dose ozone is presented as a bioregulator for chronic inflammatory diseases by helping restart redox (oxidant–antioxidant) signaling when oxidative stress is high and regulation is “stuck.” In systemic use, ozone-derived peroxidesact like a regulatory signal (similar to H₂O₂), are buffered by the glutathione system (GSH/GSSG), and trigger nuclear pathways that increase antioxidant defenses and reduce inflammatory cytokines. In rheumatoid arthritis studies, markers like SOD, catalase, and GSH rise, oxidative-stress markers fall, cytokines decrease, and clinical symptoms improve, supporting ozone as a potential complement worth testing in clinical trials.
By Viebahn-Haensler R, León Fernández OS.
International Journal of Molecular Sciences.
Published: 23 July 2021 - 2021;22(15):7890. doi:10.3390/ijms22157890.
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Medical ozone is reviewed as a promising option for musculoskeletal pain because common drug treatments (like corticosteroids and opioids) can cause significant side effects. In a review of the literature, researchers screened 249 records and included 27 clinical studies, assessing study quality, possible bias, and factors like practitioner training and device safety. Overall, ozone therapy appeared safe and effective for pain control, but many studies didn’t report key device details, and there’s still no clear “best” treatment protocol—so more rigorous, longer-term trials are needed.
By Lila T de Araújo, Patricia C da Silva, and Marcos Masini.
The Yale Journal of Biology and Medicine.
Published Sep 30 2024 - 2024;97(3):383-398. doi:10.59249/HGTG9363.
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Ozone “evidence gap map” studies suggest ozone therapy may help with pain control, infections, inflammation, wound healing, and quality of life, and it’s aimed at clinicians and researchers working in ozone care. Across the mapped evidence, no serious adverse effects were reported, supporting it as a low-cost, potentially effective integrative option. The authors highlight that future research should add economic impact analyses and evaluate how ozone treatment can be organized within health services.
By Serra MEG, Baeza-Noci J, Mendes Abdala, Luvisotto MM, Bertol, Anzolin AP
Frontiers in Public Health.
Published 16 Jan 2023 - 2022;10:1112296. doi:10.3389/fpubh.2022.1112296.
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A systematic review and meta-analysis of 12 human clinical studies found that ozone therapy can accelerate healing and reduce pain in traumatic and autoimmune oral ulcers compared with placebo, while providing similar pain reliefto topical corticosteroids and laser photobiomodulation; however, despite these promising results and formal bias assessments (ROBINS-I/RoB2), the authors note that the overall quality of evidence is limited, so more rigorous trials are needed.
By Maglia DR, Souza BDAF, Visioli F.
Clinical Oral Investigations.
Published Aug 17 2024  - 2024;28(9):490. doi:10.1007/s00784-024-05873-2.
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Low-dose ozone is described as a redox “bioregulator”: it gently shifts the body back toward a healthy oxidant–antioxidant balance. Across preclinical/clinical work (including conditions like arthritis, aging, and type 2 diabetes), it’s linked to higher antioxidant repair markers (especially glutathione) and lower oxidative-stress markers (especially malondialdehyde). Overall, “repair” activity increased ~21% to 140% vs. non-ozone groups while stress markers dropped, suggesting the redox system rebalances.
By Viebahn-Haensler R, León Fernández OS.
Molecules (Basel, Switzerland).
Published: 8 June 2024 2024;29(12):2738. doi:10.3390/molecules29122738.
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Low-dose ozone (O₃) therapy uses small, controlled oxidative stress to “train” cells to boost their own defenses without damage. It mainly works by activating Nrf2 (antioxidant response), lowering inflammatory signals/cytokines, and this can support pain reduction and tissue repair (including fibroblast activation). The paper also notes a possible anticancer effect linked to these oxidative/anti-inflammatory mechanisms.
By Malatesta M, Tabaracci G, Pellicciari C.
International Journal of Molecular Sciences.
Published: 25 November 2024 - 2024;25(23):12657. doi:10.3390/ijms252312657.
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