@article{nokey,

title = {Exploring the Potential of Stem Cell-Based Therapy for Aesthetic and Plastic Surgery},

author = {Dang-Khoa Tran and Thuy Nguyen and Thi Phuong and Nhat-Le Bui and Vijai Singh and Qi Hao Looi},

url = {https://doi.org/10.1109/RBME.2021.3134994},

doi = {https://doi.org/10.1109/RBME.2021.3134994},

year  = {2023},

date = {2023-01-05},

urldate = {2023-01-05},

abstract = {Over the last decade, stem cell-associated therapies are widely used because of their potential in self-renewable and multipotent differentiation ability. Stem cells have become more attractive for aesthetic uses and plastic surgery, including scar reduction, breast augmentation, facial contouring, hand rejuvenation, and anti-aging. The current preclinical and clinical studies of stem cells on aesthetic uses also showed promising outcomes. Adipose-derived stem cells are commonly used for fat grafting that demonstrated scar improvement, anti-aging, skin rejuvenation properties, etc. While stem cell-based products have yet to receive approval from the FDA for aesthetic medicine and plastic surgery. Moving forward, the review on the efficacy and potential of stem cell-based therapy for aesthetic and plastic surgery is limited. In the present review, we discuss the current status and recent advances of using stem cells for aesthetic and plastic surgery. The potential of cell-free therapy and tissue engineering in this field is also highlighted. The clinical applications, advantages, and limitations are also discussed. This review also provides further works that need to be investigated to widely apply stem cells in the clinic, especially in aesthetic and plastic contexts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Mesenchymal Stem Cell-derived Small Extracellular Vesicles Mitigate Oxidative Stress-induced Senescence in Endothelial Cells},

author = {Xiao X and Xu M and Yu H and Wang L and Li X and Rak J and Wang S and Zhao RC},

url = {https://doi.org/10.1038/s41392-021-00765-3},

doi = {https://doi.org/10.1038/s41392-021-00765-3},

year  = {2021},

date = {2021-10-21},

urldate = {2021-10-21},

abstract = {Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium, leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve as a promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have the potential to transfer bioactive molecules into recipient cells and induce phenotypic changes. Since mesenchymal stem cells (MSCs) have long been postulated as an important source cell in regenerative medicine, herein we investigated the role and mechanism of MSC-derived sEV (MSC-sEV) on EC senescence. In vitro results showed that MSC-sEV reduced senescent biomarkers, decreased senescence-associated secretory phenotype (SASP), rescued angiogenesis, migration and other dysfunctions in senescent EC induced by oxidative stress. In the In vivo natural aging and type-2 diabetes mouse wound-healing models (both of which have senescent ECs), MSC-sEV promoted wound closure and new blood vessel formation. Mechanically, miRNA microarray showed that miR-146a was highly expressed in MSC-sEV and also upregulated in EC after MSC-sEV treatment. miR-146a inhibitors abolished the stimulatory effects of MSC-sEV on senescence. Moreover, we found miR-146a could suppress Src phosphorylation and downstream targets VE-cadherin and Caveolin-1. Collectively, our data indicate that MSC-sEV mitigated endothelial cell senescence and stimulate angiogenesis through miR-146a/Src.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration},

author = {Ha DH and Kim HK and Lee J and Kwon HH and Park GH and Yang SH and Jung JY and Choi H and Lee JH and Sung S and Yi YW and Cho BS},

url = {https://europepmc.org/article/MED/32392899},

doi = {https://europepmc.org/article/MED/32392899},

year  = {2020},

date = {2020-05-07},

urldate = {2020-05-07},

abstract = {Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the characteristics of producer cells, exosomes can be utilized as cell-free therapeutics. Among exosomes derived from various cellular origins, mesenchymal stem cell-derived exosomes (MSC-exosomes) have gained great attention due to their immunomodulatory and regenerative functions. Indeed, many studies have shown anti-inflammatory, anti-aging and wound healing effects of MSC-exosomes in various in vitro and in vivo models. In addition, recent advances in the field of exosome biology have enabled development of specific guidelines and quality control methods, which will ultimately lead to clinical application of exosomes. This review highlights recent studies that investigate therapeutic potential of MSC-exosomes and relevant mode of actions for skin diseases, as well as quality control measures required for development of exosome-derived therapeutics.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Application of Cell Therapy for Anti-Aging Facial Skin},

author = {Farshad Zarei and Abolfazl Abbaszadeh},

url = {https://doi.org/10.2174/1574888x13666181113113415},

doi = {https://doi.org/10.2174/1574888x13666181113113415},

year  = {2019},

date = {2019-03-14},

urldate = {2019-03-14},

abstract = {The human skin undergoes the complex process of aging which is prompted by the interplay of intrinsic mechanisms and extrinsic influences. Aging is unavoidable but can be somewhat delayed. Numerous approaches have been developed to slow down facial skin aging process as it is of interest to stake holders in the beauty and fashion world as well as to plastic surgeons. Adipose-derived stem cell [ADSC] and mesenchymal stem cell [MSC] as potential anti-aging agents to some extent have provided a promising and effective alternative in managing skin and facial skin aging. Furthermore, bone marrow-derived mesenchymal stem cells [BMMSC] have exhibited similar ability to rejuvenate aged skin. This review is aimed at giving a comprehensive account of the application of stem cells especially ADSCs and MSCs to reduce or slow down the rate of facial skin aging process.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Stem Cells in Dermatology and Anti-aging Care of the Skin},

author = {Amy Forman Taub and Kim Pham},

url = {https://doi.org/10.1016/j.fsc.2018.06.004},

doi = {https://doi.org/10.1016/j.fsc.2018.06.004},

year  = {2018},

date = {2018-11-26},

urldate = {2018-11-26},

abstract = {Multipotent stem cells have paved the way for new applications and deeper understanding in regenerative medicine and the pathophysiology of aging. During skin aging, cumulative photodamage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with decreased epidermal thickness and compromised dermal integrity. Specific stem cells in the hair follicle create new keratinocytes after activation by defensin peptides, released by neutrophils during wounding. Studies pertaining to defensin peptides' efficacy on skin aging have been published, highlighting their potential as a new therapy for skin rejuvenation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Stem Cells and Healing: Impact on Inflammation},

author = {William J. Ennis and Audrey Sui and Amelia Bartholomew},

url = {https://doi.org/10.1016/j.fsc.2018.06.004},

doi = {https://doi.org/10.1016/j.fsc.2018.06.004},

year  = {2013},

date = {2013-09-02},

urldate = {2013-09-02},

abstract = {Multipotent stem cells have paved the way for new applications and deeper understanding in regenerative medicine and the pathophysiology of aging. During skin aging, cumulative photodamage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with decreased epidermal thickness and compromised dermal integrity. Specific stem cells in the hair follicle create new keratinocytes after activation by defensin peptides, released by neutrophils during wounding. Studies pertaining to defensin peptides' efficacy on skin aging have been published, highlighting their potential as a new therapy for skin rejuvenation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}